SMC2

SMC2 (Structural Maintenance Of Chromosomes 2) is a Protein Coding gene. Diseases associated with SMC2 include Pleural Empyema. Among its related pathways are Mitotic Prometaphase and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity.
Full Name
structural maintenance of chromosomes 2
Function
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Biological Process
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process kinetochore organizationIEA:Ensembl
Biological Process meiotic chromosome condensationIEA:Ensembl
Biological Process meiotic chromosome segregationIEA:Ensembl
Biological Process mitotic chromosome condensationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of chromosome condensationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process positive regulation of chromosome segregationIEA:Ensembl
Biological Process positive regulation of chromosome separationIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
Chromosome
In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
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Anti-SMC2 antibodies

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Rabbit Anti-SMC2 Recombinant Antibody (D11F9) (CBMAB-CP2515-LY)

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Target: SMC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Pig, Horse
Clone: D11F9
Application*: WB, IP
Datasheet SDS

Rabbit Anti-SMC2 Recombinant Antibody (D23C5) (CBMAB-CP2514-LY)

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Target: SMC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D23C5
Application*: WB, IP
Datasheet SDS

Rat Anti-SMC2 Recombinant Antibody (KT74) (CBMAB-S6395-CQ)

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Target: SMC2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: KT74
Application*: WB
Datasheet SDS

Mouse Anti-SMC2 Recombinant Antibody (CBXS-6146) (CBMAB-S6309-CQ)

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Target: SMC2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-6146
Application*: WB
Datasheet SDS

Rabbit Anti-SMC2 Recombinant Antibody (CBXS-2377) (CBMAB-S5135-CQ)

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Target: SMC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Rat
Clone: CBXS-2377
Application*: IP, WB
Datasheet SDS

Rabbit Anti-SMC2 Recombinant Antibody (CBXS-2376) (CBMAB-S5134-CQ)

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Target: SMC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: CBXS-2376
Application*: IP, WB
Datasheet SDS

Mouse Anti-SMC2 Recombinant Antibody (CBXS-0554) (CBMAB-S3497-CQ)

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Target: SMC2
Host: Mouse
Specificity: Human
Clone: CBXS-0554
Application*: WB
Datasheet SDS

Rabbit Anti-SMC2 Recombinant Antibody (CBXS-5448) (CBMAB-S2658-CQ)

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Target: SMC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat, Monkey
Clone: CBXS-5448
Application*: WB, IP
Datasheet SDS

Rabbit Anti-SMC2 Recombinant Antibody (CBXS-5362) (CBMAB-S2575-CQ)

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Target: SMC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXS-5362
Application*: WB, IP
Datasheet SDS

Rabbit Anti-SMC2 Recombinant Antibody (CBXS-5332) (CBMAB-S2546-CQ)

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Target: SMC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Pig, Horse
Clone: CBXS-5332
Application*: WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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