Rabbit Anti-SMC2 Recombinant Antibody (CBXS-5448) (CBMAB-S2658-CQ)

Name: Rabbit Anti-SMC2 Recombinant Antibody (CBXS-5448)
SKU: CBMAB-S2658-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

CBXS-5448

Application

WB, IP

Specificity

Human, Rat, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

structural maintenance of chromosomes 2

Introduction

SMC2 (Structural Maintenance Of Chromosomes 2) is a Protein Coding gene. Diseases associated with SMC2 include Pleural Empyema. Among its related pathways are Mitotic Prometaphase and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity.

Entrez Gene ID

Human	10592
Rat	362519
Monkey	713359

UniProt ID

Human	O95347
Rat	D4A5Q2
Monkey	F6VS74

Alternative Names

Structural Maintenance Of Chromosomes 2; SMC2 (Structural Maintenance Of Chromosomes 2, Yeast)-Like 1; Chromosome-Associated Protein E; XCAP-E Homolog; SMC Protein 2; SMC2L1; SMC-2;

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Biological Process

Biological Process cell divisionIEA:UniProtKB-KW
Biological Process kinetochore organizationIEA:Ensembl
Biological Process meiotic chromosome condensationIEA:Ensembl
Biological Process meiotic chromosome segregationIEA:Ensembl
Biological Process mitotic chromosome condensationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of chromosome condensationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process positive regulation of chromosome segregationIEA:Ensembl
Biological Process positive regulation of chromosome separationIEA:Ensembl

Cellular Location

Nucleus
Cytoplasm
Chromosome
In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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