SNF8

SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM

Full Name

SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)

Function

Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Biological Process

Biological Process early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process localizationManual Assertion Based On ExperimentIDA:DisProt
Biological Process macroautophagyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process membrane fission1 PublicationIC:ComplexPortal
Biological Process multivesicular body assemblyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process multivesicular body sorting pathwayManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of protein complex stabilityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of viral budding via host ESCRT complexManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Endosome membrane
Nucleus
Late endosome membrane
Recruited to the endosome membrane to participate in vesicle formation.