SNRPB2
The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Full Name
small nuclear ribonucleoprotein polypeptide B''
Function
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346).
Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128).
Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128).
Biological Process
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process U2-type prespliceosome assembly1 PublicationIC:ComplexPortal
Biological Process U2-type prespliceosome assembly1 PublicationIC:ComplexPortal
Cellular Location
Nucleus
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Anti-SNRPB2 antibodies
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Target: SNRPB2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F4
Application*: SE, E
Target: SNRPB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4897
Application*: WB
Target: SNRPB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4742
Application*: IC, IF, WB
Target: SNRPB2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4586
Application*: E
Target: SNRPB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4556
Application*: IC, IF, WB
Target: SNRPB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4353
Application*: WB, IH
Target: SNRPB2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4082
Application*: WB
Target: SNRPB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3877
Application*: WB
Target: SNRPB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5599
Application*: P, WB
Target: SNRPB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYS-006
Application*: IF, IP, WB
Target: SNRPB2
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYS-005
Application*: WB, IP, IF, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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