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SNUPN

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Full Name

Snurportin 1

Function

Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.

Biological Process

Biological Process protein import into nucleusIEA:InterPro
Biological Process RNA import into nucleusManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process snRNA import into nucleusIEA:InterPro

Cellular Location

Nucleus
Cytoplasm
Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920).
It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway (PubMed:10209022).

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Anti-SNUPN antibodies

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SNUPN Matched Antibody Pair (1116) (APMAB-1116LY)

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Target: SNUPN

Specificity: Human

Mouse Anti-SNUPN Recombinant Antibody (2B2-1B4) (CBMAB-A7689-LY)

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Target: SNUPN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2B2-1B4

Application*: WB, E

Mouse Anti-SNUPN Recombinant Antibody (CBXS-2843) (CBMAB-S5593-CQ)

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Target: SNUPN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-2843

Application*: E, IF, WB

Mouse Anti-SNUPN Recombinant Antibody (CBXS-0620) (CBMAB-S3561-CQ)

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Target: SNUPN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-0620

Application*: E, WB, IF

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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