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Mouse Anti-SNUPN Recombinant Antibody (CBXS-0620) (CBMAB-S3561-CQ)

This product is a mouse antibody that recognizes SNUPN. The antibody CBXS-0620 can be used for immunoassay techniques such as: ELISA, WB, IF.
See all SNUPN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0620
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IF

Basic Information

Immunogen
RNUT1 (AAH04203, 1 a.a.-360 a.a) Full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Snurportin 1
Introduction
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
Entrez Gene ID
10073
UniProt ID
O95149
Alternative Names
Snurportin 1; RNA U Transporter 1; RNUT1; RNA, U Transporter 1; Snurportin-1; Snurportin1; KPNBL; SPN1;
Function
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
Biological Process
Biological Process protein import into nucleusIEA:InterPro
Biological Process RNA import into nucleusManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process snRNA import into nucleusIEA:InterPro
Cellular Location
Nucleus
Cytoplasm
Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920).
It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway (PubMed:10209022).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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