SNX16

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The function of this protein has not been determined. This gene results in three transcript variants encoding two distinct isoforms. [provided by RefSeq]

Full Name

sorting nexin 16

Function

May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.

Biological Process

Biological Process early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosome to lysosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein targeting to lysosomeManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Early endosome membrane
Late endosome membrane
Cytoplasm
Lysosome