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SPTAN1

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Full Name
Spectrin alpha chain, non-erythrocytic 1
Function
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process actin filament cappingIEA:UniProtKB-KW
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, cell cortex
Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
Involvement in disease
Developmental and epileptic encephalopathy 5 (DEE5):
A disorder characterized by seizures associated with hypsarrhythmia, profound intellectual disability with lack of visual attention and speech development, as well as spastic quadriplegia.
PTM
Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.
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Anti-SPTAN1 antibodies

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Mouse Anti-SPTAN1 Recombinant Antibody (D8B7) (CBMAB-A4828-YC)

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Target: SPTAN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Sheep, Monkey
Clone: D8B7
Application*: WB, IP, E, P, C, IC, IF
Datasheet SDS

Mouse Anti-SPTAN1 Recombinant Antibody (AA6) (CBMAB-1825-CN)

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Target: SPTAN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: AA6
Application*: IH, WB
Datasheet SDS

Mouse Anti-SPTAN1 Recombinant Antibody (CBMAB-BR454LY)

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Target: SPTAN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse
Application*: IHC, WB
Datasheet SDS

Mouse Anti-SPTAN1 Recombinant Antibody (CBXS-2973) (CBMAB-S5720-CQ)

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Target: SPTAN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Guinea pig, Human, Rabbit, Rat
Clone: CBXS-2973
Application*: IF, IH, WB
Datasheet SDS

Mouse Anti-SPTAN1 Recombinant Antibody (CBXS-2484) (CBMAB-S5241-CQ)

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Target: SPTAN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human
Clone: CBXS-2484
Application*: IF, WB
Datasheet SDS

Mouse Anti-SPTAN1 Recombinant Antibody (CBXS-0695) (CBMAB-S3632-CQ)

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Target: SPTAN1
Host: Mouse
Specificity: Human
Clone: CBXS-0695
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SPTAN1 Recombinant Antibody (CBXS-0694) (CBMAB-S3631-CQ)

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Target: SPTAN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0694
Application*: IF, P, WB
Datasheet SDS

Rabbit Anti-SPTAN1 Recombinant Antibody (CBXS-5474) (CBMAB-S2684-CQ)

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Target: SPTAN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBXS-5474
Application*: IF, WB, IP, P
Datasheet SDS

Rabbit Anti-SPTAN1 (Internal) Recombinant Antibody (CBXS-5470) (CBMAB-S2680-CQ)

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Target: SPTAN1
Host: Rabbit
Specificity: Human
Clone: CBXS-5470
Application*: P, IP, WB
Datasheet SDS

Mouse Anti-SPTAN1 Recombinant Antibody (CBXS-5441) (CBMAB-S2652-CQ)

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Target: SPTAN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5441
Application*: E, IF, C, WB
Datasheet SDS

Mouse Anti-SPTAN1 Recombinant Antibody (CBXS-4852) (CBMAB-S2075-CQ)

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Target: SPTAN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4852
Application*: IC, IF, WB
Datasheet SDS

Mouse Anti-SPTAN1 Recombinant Antibody (CBXF-3297) (CBMAB-F3991-CQ)

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Target: SPTAN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-3297
Application*: IF, WB
Datasheet SDS

Mouse Anti-SPTAN1 Recombinant Antibody (3D7) (CBMAB-1824-CN)

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Target: SPTAN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Cattle
Clone: 3D7
Application*: WB, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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