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Mouse Anti-SPTAN1 Recombinant Antibody (CBMAB-BR454LY)

The product is antibody recognizes SPTAN1. The antibody immunoassay techniques such as: IHC, WB.
See all SPTAN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey, Mouse
Antibody Isotype
IgG
Application
IHC: 1:300-1:500 dilution, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
Recombinant construct containing the 19th and 20th spectrin repeats and C-terminal EF hand domains of human ?II spectrin (amino acids 2086-2445 from AAB41498.1) expressed in and purified from E. coli.
Specificity
Human, Monkey, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
5mM sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Spectrin alpha chain, non-erythrocytic 1
Introduction
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Entrez Gene ID
Human6709
Mouse20740
Monkey722610
UniProt ID
HumanQ13813
MouseP16546
MonkeyF7HJP9
Alternative Names
Spectrin alpha chain, non-erythrocytic 1;Alpha-II spectrin;Fodrin alpha chain;Spectrin, non-erythroid alpha subunit;SPTAN1;NEAS, SPTA2;
Function
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process actin filament cappingIEA:UniProtKB-KW
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, cell cortex
Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
Involvement in disease
Developmental and epileptic encephalopathy 5 (DEE5):
A disorder characterized by seizures associated with hypsarrhythmia, profound intellectual disability with lack of visual attention and speech development, as well as spastic quadriplegia.
PTM
Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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