SRC1

SRC1

Biological Process activation of protein kinase B activityIEA:Ensembl
Biological Process adherens junction organizationIEA:Ensembl
Biological Process angiotensin-activated signaling pathway involved in heart processISS:BHF-UCL
Biological Process bone resorptionISS:UniProtKB
Biological Process branching involved in mammary gland duct morphogenesisIEA:Ensembl
Biological Process cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell-cell adhesionIEA:Ensembl
Biological Process cellular response to fatty acidIEA:Ensembl
Biological Process cellular response to fluid shear stressIEA:Ensembl
Biological Process cellular response to hydrogen peroxideIEA:Ensembl
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process cellular response to insulin stimulusIEA:Ensembl
Biological Process cellular response to lipopolysaccharideIEA:Ensembl
Biological Process cellular response to peptide hormone stimulusISS:BHF-UCL
Biological Process cellular response to platelet-derived growth factor stimulusIEA:Ensembl
Biological Process cellular response to progesterone stimulusISS:BHF-UCL
Biological Process cellular response to prolactinIEA:Ensembl
Biological Process DNA biosynthetic processIEA:Ensembl
Biological Process entry of bacterium into host cellTAS:Reactome
Biological Process ephrin receptor signaling pathwayTAS:Reactome
Biological Process epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ERBB2 signaling pathwayTAS:Reactome
Biological Process Fc-gamma receptor signaling pathway involved in phagocytosisTAS:Reactome
Biological Process focal adhesion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process forebrain developmentIEA:Ensembl
Biological Process innate immune responseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process interleukin-6-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intestinal epithelial cell developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process learning or memoryIEA:Ensembl
Biological Process leukocyte migrationTAS:Reactome
Biological Process macroautophagyTAS:Reactome
Biological Process myoblast proliferationIEA:Ensembl
Biological Process negative regulation of anoikisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionIEA:Ensembl
Biological Process negative regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of focal adhesion assemblyISS:BHF-UCL
Biological Process negative regulation of inflammatory response to antigenic stimulusTAS:Reactome
Biological Process negative regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of mitochondrial depolarizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of telomerase activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process neurotrophin TRK receptor signaling pathwayIEA:Ensembl
Biological Process odontogenesisIEA:Ensembl
Biological Process oogenesisIEA:Ensembl
Biological Process osteoclast developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process peptidyl-serine phosphorylationIEA:Ensembl
Biological Process peptidyl-tyrosine autophosphorylationIEA:Ensembl
Biological Process peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process platelet activationTAS:Reactome
Biological Process positive regulation of apoptotic processIEA:Ensembl
Biological Process positive regulation of bone resorptionIEA:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathwayIEA:Ensembl
Biological Process positive regulation of cyclin-dependent protein serine/threonine kinase activityIEA:Ensembl
Biological Process positive regulation of cytokine productionIEA:Ensembl
Biological Process positive regulation of dephosphorylationManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process positive regulation of DNA biosynthetic processIEA:Ensembl
Biological Process positive regulation of DNA-templated transcriptionIEA:Ensembl
Biological Process positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Biological Process positive regulation of glucose metabolic processIEA:Ensembl
Biological Process positive regulation of hippo signalingManual Assertion Based On ExperimentIMP:FlyBase
Biological Process positive regulation of insulin receptor signaling pathwayIEA:Ensembl
Biological Process positive regulation of integrin activationManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process positive regulation of lamellipodium morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of male germ cell proliferationIEA:Ensembl
Biological Process positive regulation of MAP kinase activityIEA:Ensembl
Biological Process positive regulation of non-membrane spanning protein tyrosine kinase activity1 PublicationNAS:ARUK-UCL
Biological Process positive regulation of Notch signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of ovarian follicle developmentIEA:Ensembl
Biological Process positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process positive regulation of phosphatidylinositol 3-kinase activityIEA:Ensembl
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingTAS:Reactome
Biological Process positive regulation of platelet-derived growth factor receptor-beta signaling pathwayIEA:Ensembl
Biological Process positive regulation of podosome assemblyIEA:Ensembl
Biological Process positive regulation of protein autophosphorylationIEA:Ensembl
Biological Process positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein localization to nucleusIEA:Ensembl
Biological Process positive regulation of protein processingIEA:Ensembl
Biological Process positive regulation of protein serine/threonine kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein transportIEA:Ensembl
Biological Process positive regulation of Ras protein signal transductionIEA:Ensembl
Biological Process positive regulation of small GTPase mediated signal transductionManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process positive regulation of smooth muscle cell migrationIEA:Ensembl
Biological Process positive regulation of vascular associated smooth muscle cell proliferationIEA:Ensembl
Biological Process primary ovarian follicle growthIEA:Ensembl
Biological Process progesterone receptor signaling pathwayISS:BHF-UCL
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein destabilizationIEA:Ensembl
Biological Process regulation of bone resorptionManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of caveolin-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell projection assemblyIEA:Ensembl
Biological Process regulation of cell-cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of intracellular estrogen receptor signaling pathwayIEA:Ensembl
Biological Process regulation of postsynaptic neurotransmitter receptor activityIEA:Ensembl
Biological Process regulation of protein bindingIEA:Ensembl
Biological Process regulation of vascular permeabilityManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process response to acidic pHIEA:Ensembl
Biological Process response to electrical stimulusIEA:Ensembl
Biological Process response to interleukin-1Manual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process response to mechanical stimulusIEA:Ensembl
Biological Process response to mineralocorticoidIEA:Ensembl
Biological Process response to nutrient levelsIEA:Ensembl
Biological Process response to virusIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process signal complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process skeletal muscle cell proliferationIEA:Ensembl
Biological Process spermatogenesisIEA:Ensembl
Biological Process stimulatory C-type lectin receptor signaling pathwayTAS:Reactome
Biological Process stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process substrate adhesion-dependent cell spreadingIEA:Ensembl
Biological Process T cell costimulationTAS:Reactome
Biological Process transcytosisIEA:Ensembl
Biological Process transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process uterus developmentIEA:Ensembl
Biological Process vascular endothelial growth factor receptor signaling pathwayTAS:Reactome

Cell membrane
Mitochondrion inner membrane
Nucleus
Cytoplasm, cytoskeleton
Cytoplasm, perinuclear region
Cell junction, focal adhesion
Localizes to focal adhesion sites following integrin engagement (PubMed:22801373).
Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268).
Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596).

Thrombocytopenia 6 (THC6):
A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC6 is an autosomal dominant form. Affected individuals may also have bone abnormalities and an increased risk for myelofibrosis.

Myristoylated at Gly-2, and this is essential for targeting to membranes.
Dephosphorylated at Tyr-530 by PTPRJ (By similarity).
Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-419. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-530, the SH3 domain engaged with the SH2-kinase linker, and Tyr-419 dephosphorylated. Dephosphorylation of Tyr-530 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-530, Tyr-419 can then become autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-530 by CSK allows this interaction to reform, resulting in SRC inactivation. CDK5-mediated phosphorylation at Ser-75 targets SRC to ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. Phosphorylated by PTK2/FAK1; this enhances kinase activity. Phosphorylated by PTK2B/PYK2; this enhances kinase activity. Upon activation of IL6ST by IL6, Tyr-419 is phosphorylated and Tyr-530 dephosphorylated (PubMed:25731159).
Isoform 1
Displays reduced levels of autophosphorylation at Tyr-419 compared to isoforms 2 and 3.
Isoform 2
Displays enhanced levels of autophosphorylation at Tyr-419 compared to isoform 1.
Isoform 3
Displays enhanced levels of autophosphorylation at Tyr-419 compared to isoform 1 (By similarity).
Shows reduced phosphorylation at Tyr-527 compared to isoforms 1 and 2 (By similarity).
S-nitrosylation is important for activation of its kinase activity.
Ubiquitinated in response to CDK5-mediated phosphorylation. Ubiquitination mediated by CBLC requires SRC autophosphorylation at Tyr-419 and may lead to lysosomal degradation.