SRGAP3

SRGAP3 (SLIT-ROBO Rho GTPase Activating Protein 3) is a Protein Coding gene. Diseases associated with SRGAP3 include Pilocytic Astrocytoma and Chromosome 3Pter-P25 Deletion Syndrome. Among its related pathways are Developmental Biology and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rac GTPase binding. An important paralog of this gene is SRGAP1.

SLIT-ROBO Rho GTPase activating protein 3

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.

Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome
Biological Process signal transductionIEA:InterPro

cytoplasm
cytosol

A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic intellectual disability (PubMed:12195014). Translocation t(X;3)(p11.2;p25) (PubMed:12195014).