SRGAP3

SRGAP3 (SLIT-ROBO Rho GTPase Activating Protein 3) is a Protein Coding gene. Diseases associated with SRGAP3 include Pilocytic Astrocytoma and Chromosome 3Pter-P25 Deletion Syndrome. Among its related pathways are Developmental Biology and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rac GTPase binding. An important paralog of this gene is SRGAP1.

Full Name

SLIT-ROBO Rho GTPase activating protein 3

Function

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.

Biological Process

Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome
Biological Process signal transductionIEA:InterPro

Cellular Location

cytoplasm
cytosol

Involvement in disease

A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic intellectual disability (PubMed:12195014). Translocation t(X;3)(p11.2;p25) (PubMed:12195014).