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Mouse Anti-SRGAP3 Recombinant Antibody (CBWJW-132) (CBMAB-S0001-WJ)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBWJW-132
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SLIT-ROBO Rho GTPase activating protein 3
Introduction
SRGAP3 is a protein-coding gene. Diseases associated with SRGAP3 include Pilocytic Astrocytoma and Chromosome 3Pter-P25 Deletion Syndrome. Its related pathways are Developmental Biology and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rac GTPase binding. SRGAP1 is an important paralog of this gene.
Entrez Gene ID
Human9901
Mouse259302
Rat500287
UniProt ID
HumanO43295
MouseQ812A2
RatF1M5M9
Alternative Names
WRP; MEGAP; SRGAP2; ARHGAP14
Function
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.
Biological Process
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome
Biological Process signal transductionIEA:InterPro
Cellular Location
cytoplasm
cytosol
Involvement in disease
A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic intellectual disability (PubMed:12195014). Translocation t(X;3)(p11.2;p25) (PubMed:12195014).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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