SRXN1

SRXN1 (Sulfiredoxin 1) is a Protein Coding gene. Among its related pathways are Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on a sulfur group of donors and sulfiredoxin activity.

Sulfiredoxin 1

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 (PubMed:15448164, PubMed:15590625).
Does not act on PRDX5 or PRDX6 (PubMed:15448164, PubMed:15590625).
May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (PubMed:15448164, PubMed:15590625).

Biological Process cellular response to chemical stressTAS:Reactome
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to oxidative stressManual Assertion Based On ExperimentIDA:UniProtKB

Cytoplasm