ST8SIA2

The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq]

Full Name

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

Function

May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.

Biological Process

Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process ganglioside biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process N-glycan processingManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuron projection extensionIEA:Ensembl
Biological Process oligosaccharide metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of neuron deathIEA:Ensembl
Biological Process positive regulation of synapse assemblyIEA:Ensembl
Biological Process protein glycosylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein modification processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process response to cocaineIEA:Ensembl

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-6
Helical: 7-23
Lumenal: 24-375