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Mouse Anti-ST8SIA2 Recombinant Antibody (CBXS-3495) (CBMAB-S6225-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3495
Antibody Isotype
IgG
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant human ST8Sia II (aa40-147) with a GST tag
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Introduction
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.
Entrez Gene ID
8128
UniProt ID
Q92186
Alternative Names
HsT19690; SIAT8-B; SIAT8B; ST8SIA-II; ST8SiaII; STX
Function
May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.
Biological Process
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process ganglioside biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process N-glycan processingManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuron projection extensionIEA:Ensembl
Biological Process oligosaccharide metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of neuron deathIEA:Ensembl
Biological Process positive regulation of synapse assemblyIEA:Ensembl
Biological Process protein glycosylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein modification processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process response to cocaineIEA:Ensembl
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-6
Helical: 7-23
Lumenal: 24-375
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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