STAM

This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte grwoth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein. [provided by RefSeq]

Full Name

signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
(Microbial infection) Plays an important role in Dengue virus entry.

Biological Process

Biological Process macroautophagyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process membrane fission1 PublicationIC:ComplexPortal
Biological Process multivesicular body assemblyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm
Early endosome membrane

PTM

Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
Ubiquitinated by ITCH.