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Mouse Anti-STAM Recombinant Antibody (29C678) (CBMAB-S0237-CQ)

This product is a mouse antibody that recognizes STAM. The antibody 29C678 can be used for immunoassay techniques such as: WB.
See all STAM antibodies
Published Data
Fig.1 Validation of the interaction between EphB2 and endogenous STAM1 or VPS4A by co-IP/Western blot (WB) analysis in HEK293 cells stably expressing EphB2.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
29C678
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Synthetic peptide corresponding to amino acids 149-165 of human STAM
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Introduction
This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene.
Entrez Gene ID
8027
UniProt ID
Q92783
Alternative Names
STAM-1; STAM1
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
(Microbial infection) Plays an important role in Dengue virus entry.
Biological Process
Biological Process macroautophagyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process membrane fission1 PublicationIC:ComplexPortal
Biological Process multivesicular body assemblyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Early endosome membrane
PTM
Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
Ubiquitinated by ITCH.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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