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STAM2

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq]
Full Name
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
Biological Process
Biological Process macroautophagyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process membrane fission1 PublicationIC:ComplexPortal
Biological Process multivesicular body assemblyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway1 PublicationIC:ComplexPortal
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Early endosome membrane
PTM
Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
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Anti-STAM2 antibodies

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Rabbit Anti-STAM2 Recombinant Antibody (D8B3G) (CBMAB-CP2586-LY)

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Target: STAM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D8B3G
Application*: WB, IP
Datasheet SDS

Mouse Anti-STAM2 Recombinant Antibody (1A10) (CBMAB-A8635-LY)

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Target: STAM2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1A10
Application*: WB, E
Datasheet SDS

Mouse Anti-STAM2 Recombinant Antibody (G1G5) (CBMAB-S6339-CQ)

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Target: STAM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: G1G5
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-STAM2 Recombinant Antibody (CBXS-2660) (CBMAB-S5412-CQ)

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Target: STAM2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2660
Application*: E, IP, WB
Datasheet SDS

Rabbit Anti-STAM2 Recombinant Antibody (CBXS-1612) (CBMAB-S4461-CQ)

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Target: STAM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1612
Application*: WB, P, F, IF
Datasheet SDS

Rabbit Anti-STAM2 Recombinant Antibody (CBXS-0751) (CBMAB-S3679-CQ)

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Target: STAM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBXS-0751
Application*: WB, IP
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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