STEAP4

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Full Name

STEAP4 Metalloreductase

Function

Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe3+ chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe3+ chelate (PubMed:30337524).
Can also reduce Cu2+ to Cu1+ (By similarity).
Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).
Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574).
Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107).
Inhibits anchorage-independent cell proliferation (PubMed:19787193).

Biological Process

Biological Process copper ion importManual Assertion Based On ExperimentIBA:GO_Central
Biological Process fat cell differentiationISS:UniProtKB
Biological Process iron import into cellIEA:Ensembl
Biological Process protein homotrimerizationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell membrane
Golgi apparatus membrane
Early endosome membrane