Mouse Anti-STEAP4 Recombinant Antibody (CBXS-1823) (CBMAB-S0123-CQ)

Name: Mouse Anti-STEAP4 Recombinant Antibody (CBXS-1823)
SKU: CBMAB-S0123-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-1823

Application

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

STEAP4 Metalloreductase

Introduction

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

79689

UniProt ID

Q687X5

Alternative Names

STAMP2; SchLAH; TIARP; TNFAIP9

Function

Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe3+ chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe3+ chelate (PubMed:30337524).
Can also reduce Cu2+ to Cu1+ (By similarity).
Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).
Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574).
Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107).
Inhibits anchorage-independent cell proliferation (PubMed:19787193).

Biological Process

Biological Process copper ion importManual Assertion Based On ExperimentIBA:GO_Central
Biological Process fat cell differentiationISS:UniProtKB
Biological Process iron import into cellIEA:Ensembl
Biological Process protein homotrimerizationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell membrane
Golgi apparatus membrane
Early endosome membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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