STX12

STX12 (Syntaxin 12) is a Protein Coding gene. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Phagosome. Gene Ontology (GO) annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is STX7.SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
Full Name
syntaxin 12
Function
SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Biological Process
Biological Process autophagosome assemblyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process cholesterol effluxManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process endocytic recyclingISS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein stabilizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endosome membrane
Golgi apparatus membrane
Endomembrane system
Early endosome membrane
Recycling endosome membrane
Topology
Cytoplasmic: 2-248
Helical: 249-269
Vesicular: 270-276
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Anti-STX12 antibodies

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Mouse Anti-STX12 Recombinant Antibody (3B9) (CBMAB-A8743-LY)

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Target: STX12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B9
Application*: WB, E
Datasheet SDS

Mouse Anti-STX12 Recombinant Antibody (CBXS-3028) (CBMAB-S5774-CQ)

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Target: STX12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3028
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-STX12 Recombinant Antibody (CBXS-2415) (CBMAB-S5172-CQ)

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Target: STX12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2415
Application*: WB
Datasheet SDS

Mouse Anti-STX12 Recombinant Antibody (CBXS-1886) (CBMAB-S4680-CQ)

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Target: STX12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1886
Application*: WB
Datasheet SDS

Mouse Anti-STX12 Recombinant Antibody (CBXS-0813) (CBMAB-S3740-CQ)

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Target: STX12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-0813
Application*: IC, WB
Datasheet SDS

Mouse Anti-STX12 Recombinant Antibody (CBXS-0812) (CBMAB-S3739-CQ)

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Target: STX12
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBXS-0812
Application*: IC, WB
Datasheet SDS

Mouse Anti-STX12 Recombinant Antibody (CBXS-0811) (CBMAB-S3738-CQ)

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Target: STX12
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Dog, Hamster
Clone: CBXS-0811
Application*: WB, P
Datasheet SDS

Mouse Anti-STX12 Recombinant Antibody (CBXS-5687) (CBMAB-S0557-CQ)

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Target: STX12
Host: Mouse
Antibody Isotype: IgG
Specificity: Dog, Hamster, Mouse, Rat
Clone: CBXS-5687
Application*: IC, IF, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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