STX12

STX12 (Syntaxin 12) is a Protein Coding gene. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Phagosome. Gene Ontology (GO) annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is STX7.SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).

syntaxin 12

SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.

Biological Process autophagosome assemblyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process cholesterol effluxManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process endocytic recyclingISS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein stabilizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central

Endosome membrane
Golgi apparatus membrane
Endomembrane system
Early endosome membrane
Recycling endosome membrane

Cytoplasmic: 2-248
Helical: 249-269
Vesicular: 270-276