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Mouse Anti-STX12 Recombinant Antibody (CBXS-0811) (CBMAB-S3738-CQ)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Dog, Hamster
Clone
CBXS-0811
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Specificity
Mouse, Rat, Dog, Hamster
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
syntaxin 12
Introduction
STX12 (Syntaxin 12) is a Protein Coding gene. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Phagosome. Gene Ontology (GO) annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is STX7.SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
Entrez Gene ID
Hamster101824370
Mouse100226
Rat65033
Dog478168
UniProt ID
HamsterG3H204
MouseQ9ER00
RatG3V7P1
DogA0A8I3NIZ9
Alternative Names
AI850350; AU041521; Stx13
Function
SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Biological Process
Biological Process autophagosome assemblyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process cholesterol effluxManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process endocytic recyclingISS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein stabilizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endosome membrane
Golgi apparatus membrane
Endomembrane system
Early endosome membrane
Recycling endosome membrane
Topology
Cytoplasmic: 2-248
Helical: 249-269
Vesicular: 270-276
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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