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STX1A

Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM
Full Name
STX1A
Function
Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000).
Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057).
Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity).
Biological Process
Biological Process calcium-ion regulated exocytosisIEA:Ensembl
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process insulin secretionIEA:Ensembl
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of calcium ion-dependent exocytosisISS:UniProtKB
Biological Process positive regulation of catecholamine secretionISS:UniProtKB
Biological Process positive regulation of excitatory postsynaptic potentialIEA:Ensembl
Biological Process positive regulation of neurotransmitter secretionIEA:Ensembl
Biological Process positive regulation of norepinephrine secretionISS:UniProtKB
Biological Process protein localization to membraneIEA:Ensembl
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of insulin secretionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of synaptic vesicle primingIEA:Ensembl
Biological Process response to gravityIEA:Ensembl
Biological Process secretion by cellManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process SNARE complex assemblyIEA:Ensembl
Biological Process synaptic vesicle dockingIEA:Ensembl
Biological Process synaptic vesicle endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process synaptic vesicle exocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process synaptic vesicle fusion to presynaptic active zone membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Synapse, synaptosome
Cell membrane
Colocalizes with KCNB1 at the cell membrane.
Isoform 2
Secreted
Involvement in disease
STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Topology
Cytoplasmic: 1-265
Helical: 266-286
Extracellular: 287-288
PTM
Phosphorylated by CK2 (By similarity).
Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1.
Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis.

Anti-STX1A antibodies

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Target: STX1A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP36
Application*: P
Target: STX1A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM367
Application*: IHC, WB
Target: STX1A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D4E2W
Application*: WB
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 1F9-1C9
Application*: WB, E
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B11-1A8
Application*: WB, E
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: HPC-1
Application*: WB, IH, IP, P
Target: STX1A
Host: Mouse
Specificity: Human
Clone: CBXS-2789
Application*: E, WB
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: CBXS-2686
Application*: E, IF, WB
Target: STX1A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1930
Application*: WB, IH
Target: STX1A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1270
Application*: WB, IP
Target: STX1A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1269
Application*: WB, IP, F
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0826
Application*: SE, E, WB
Target: STX1A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Mouse
Clone: CBXS-0825
Application*: IC, IP, WB
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse, Zebrafish
Clone: CBXS-0824
Application*: IC, IH
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse, Zebrafish
Clone: CBXS-0823
Application*: IC, IH, WB, E
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Rabbit, Cattle
Clone: CBXS-0822
Application*: IF, WB
Target: STX1A
Host: Mouse
Specificity: Human
Clone: CBXS-0821
Application*: WB, IC, P, C, E
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0820
Application*: E, WB
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0819
Application*: E, P, WB
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Pig, Rat, Cat, Hamster, Frog, Cattle
Clone: CBXS-5704
Application*: WB
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: SP6
Application*: E, F, IC, IF, P, WB
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Pig, Hamster
Clone: SP8
Application*: WB, E, F, IF
Target: STX1A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: SP-6
Application*: WB, IH, IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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