Mouse Anti-STX1A Recombinant Antibody (CBXS-0822) (CBMAB-S3746-CQ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057).
Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity).
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process insulin secretionIEA:Ensembl
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of calcium ion-dependent exocytosisISS:UniProtKB
Biological Process positive regulation of catecholamine secretionISS:UniProtKB
Biological Process positive regulation of excitatory postsynaptic potentialIEA:Ensembl
Biological Process positive regulation of neurotransmitter secretionIEA:Ensembl
Biological Process positive regulation of norepinephrine secretionISS:UniProtKB
Biological Process protein localization to membraneIEA:Ensembl
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of insulin secretionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of synaptic vesicle primingIEA:Ensembl
Biological Process response to gravityIEA:Ensembl
Biological Process secretion by cellManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process SNARE complex assemblyIEA:Ensembl
Biological Process synaptic vesicle dockingIEA:Ensembl
Biological Process synaptic vesicle endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process synaptic vesicle exocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process synaptic vesicle fusion to presynaptic active zone membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central
Synapse, synaptosome
Cell membrane
Colocalizes with KCNB1 at the cell membrane.
Isoform 2
Secreted
Helical: 266-286
Extracellular: 287-288
Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1.
Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Antibody Pairs
STX1A Matched Antibody Pair (1161) (CAT#: APMAB-1161LY)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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