STXBP5

Stxbp5 is a syntaxin-binding protein implicated in the formation of complexes involved in neurotransmitter release.

Full Name

Syntaxin Binding Protein 5

Function

Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity).

Biological Process

Biological Process exocytosisIEA:UniProtKB-KW
Biological Process positive regulation of exocytosisISS:BHF-UCL
Biological Process protein transportIEA:UniProtKB-KW
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process regulation of synaptic vesicle primingIEA:Ensembl

Cellular Location

Cytoplasm
Cell membrane
Cytoplasmic vesicle membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
Synapse
Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles (By similarity).