SYT4

SYT4 (Synaptotagmin 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT11.May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

synaptotagmin IV

Synaptotagmin family member which does not bind Ca2+ (PubMed:23999003) (By similarity).
Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (By similarity).
Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process dense core granule cytoskeletal transportISS:UniProtKB
Biological Process memoryIEA:Ensembl
Biological Process negative regulation of calcium ion-dependent exocytosisNAS:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of catecholamine secretionIGI:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of protein secretionIEA:Ensembl
Biological Process negative regulation of retrograde trans-synaptic signaling by neuropeptideIEA:Ensembl
Biological Process negative regulation of short-term neuronal synaptic plasticityIEA:Ensembl
Biological Process negative regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process neurotransmitter secretionIEA:Ensembl
Biological Process positive regulation of calcium ion-dependent exocytosisNAS:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of dendrite extensionIDA:UniProtKB1 Publication
Biological Process positive regulation of dense core granule exocytosisIEA:Ensembl
Biological Process positive regulation of glutamate secretionIEA:Ensembl
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process regulation of endocytosisIEA:Ensembl
Biological Process regulation of presynaptic dense core granule exocytosisIEA:Ensembl
Biological Process regulation of vesicle fusionIEA:Ensembl
Biological Process trans-synaptic signaling by BDNF, modulating synaptic transmissionIEA:Ensembl
Biological Process vesicle fusionIBA:GO_Central1 Publication
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication

Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane

Vesicular: 1-16
Helical: 17-37
Cytoplasmic: 38-425

Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility.