SYT4
SYT4 (Synaptotagmin 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT11.May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Full Name
synaptotagmin IV
Function
Synaptotagmin family member which does not bind Ca2+ (PubMed:23999003) (By similarity).
Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (By similarity).
Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (By similarity).
Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Biological Process
Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process dense core granule cytoskeletal transportISS:UniProtKB
Biological Process memoryIEA:Ensembl
Biological Process negative regulation of calcium ion-dependent exocytosisNAS:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of catecholamine secretionIGI:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of protein secretionIEA:Ensembl
Biological Process negative regulation of retrograde trans-synaptic signaling by neuropeptideIEA:Ensembl
Biological Process negative regulation of short-term neuronal synaptic plasticityIEA:Ensembl
Biological Process negative regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process neurotransmitter secretionIEA:Ensembl
Biological Process positive regulation of calcium ion-dependent exocytosisNAS:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of dendrite extensionIDA:UniProtKB1 Publication
Biological Process positive regulation of dense core granule exocytosisIEA:Ensembl
Biological Process positive regulation of glutamate secretionIEA:Ensembl
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process regulation of endocytosisIEA:Ensembl
Biological Process regulation of presynaptic dense core granule exocytosisIEA:Ensembl
Biological Process regulation of vesicle fusionIEA:Ensembl
Biological Process trans-synaptic signaling by BDNF, modulating synaptic transmissionIEA:Ensembl
Biological Process vesicle fusionIBA:GO_Central1 Publication
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process dense core granule cytoskeletal transportISS:UniProtKB
Biological Process memoryIEA:Ensembl
Biological Process negative regulation of calcium ion-dependent exocytosisNAS:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of catecholamine secretionIGI:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of protein secretionIEA:Ensembl
Biological Process negative regulation of retrograde trans-synaptic signaling by neuropeptideIEA:Ensembl
Biological Process negative regulation of short-term neuronal synaptic plasticityIEA:Ensembl
Biological Process negative regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process neurotransmitter secretionIEA:Ensembl
Biological Process positive regulation of calcium ion-dependent exocytosisNAS:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of dendrite extensionIDA:UniProtKB1 Publication
Biological Process positive regulation of dense core granule exocytosisIEA:Ensembl
Biological Process positive regulation of glutamate secretionIEA:Ensembl
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process regulation of endocytosisIEA:Ensembl
Biological Process regulation of presynaptic dense core granule exocytosisIEA:Ensembl
Biological Process regulation of vesicle fusionIEA:Ensembl
Biological Process trans-synaptic signaling by BDNF, modulating synaptic transmissionIEA:Ensembl
Biological Process vesicle fusionIBA:GO_Central1 Publication
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane
Topology
Vesicular: 1-16
Helical: 17-37
Cytoplasmic: 38-425
Helical: 17-37
Cytoplasmic: 38-425
PTM
Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility.
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Anti-SYT4 antibodies
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CompareTarget: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4412
Application*: P, WB
Target: Syt4
Sensitivity: 0.0016 ng/mL
Detection Range: 0.003-0.9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: SYT4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 5F8
Application*: WB, E
Target: SYT4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXS-3302
Application*: E, IF, WB
Target: SYT4
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXS-0921
Application*: E, IF, WB
Target: SYT4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXS-0920
Application*: SE, E, WB, IF
Target: SYT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5562
Application*: IH
Target: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5105
Application*: WB, IH, IF
Target: SYT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5061
Application*: IF, WB
Target: SYT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4856
Application*: IF, WB
Target: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4846
Application*: WB
Target: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4776
Application*: WB
Target: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4578
Application*: IF, P, WB
Target: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4488
Application*: IF, P, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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