SYT4

SYT4 (Synaptotagmin 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT11.May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Full Name
synaptotagmin IV
Function
Synaptotagmin family member which does not bind Ca2+ (PubMed:23999003) (By similarity).
Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (By similarity).
Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Biological Process
Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process dense core granule cytoskeletal transportISS:UniProtKB
Biological Process memoryIEA:Ensembl
Biological Process negative regulation of calcium ion-dependent exocytosisNAS:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of catecholamine secretionIGI:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of protein secretionIEA:Ensembl
Biological Process negative regulation of retrograde trans-synaptic signaling by neuropeptideIEA:Ensembl
Biological Process negative regulation of short-term neuronal synaptic plasticityIEA:Ensembl
Biological Process negative regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process neurotransmitter secretionIEA:Ensembl
Biological Process positive regulation of calcium ion-dependent exocytosisNAS:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of dendrite extensionIDA:UniProtKB1 Publication
Biological Process positive regulation of dense core granule exocytosisIEA:Ensembl
Biological Process positive regulation of glutamate secretionIEA:Ensembl
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process regulation of endocytosisIEA:Ensembl
Biological Process regulation of presynaptic dense core granule exocytosisIEA:Ensembl
Biological Process regulation of vesicle fusionIEA:Ensembl
Biological Process trans-synaptic signaling by BDNF, modulating synaptic transmissionIEA:Ensembl
Biological Process vesicle fusionIBA:GO_Central1 Publication
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane
Topology
Vesicular: 1-16
Helical: 17-37
Cytoplasmic: 38-425
PTM
Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility.
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Anti-SYT4 antibodies

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Mouse Anti-SYT4 Recombinant Antibody (CBXS-4412) (CBMAB-S1654-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4412
Application*: P, WB
Datasheet SDS

Mouse Anti-SYT4 Recombinant Antibody (5F8) (CBMAB-A8820-LY)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 5F8
Application*: WB, E
Datasheet SDS

Mouse Anti-SYT4 Recombinant Antibody (CBXS-3302) (CBMAB-S6041-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXS-3302
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-SYT4 (AA 1-100) Recombinant Antibody (CBXS-0921) (CBMAB-S3836-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXS-0921
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-SYT4 Recombinant Antibody (CBXS-0920) (CBMAB-S3835-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXS-0920
Application*: SE, E, WB, IF
Datasheet SDS

Mouse Anti-SYT4 Recombinant Antibody (CBXS-5562) (CBMAB-S2769-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5562
Application*: IH
Datasheet SDS

Mouse Anti-SYT4 Recombinant Antibody (CBXS-5105) (CBMAB-S2323-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5105
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-SYT4 Recombinant Antibody (CBXS-5061) (CBMAB-S2282-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5061
Application*: IF, WB
Datasheet SDS

Mouse Anti-SYT4 Recombinant Antibody (CBXS-4856) (CBMAB-S2079-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4856
Application*: IF, WB
Datasheet SDS

Mouse Anti-SYT4 Recombinant Antibody (CBXS-4846) (CBMAB-S2070-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4846
Application*: WB
Datasheet SDS

Mouse Anti-SYT4 Recombinant Antibody (CBXS-4776) (CBMAB-S2003-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4776
Application*: WB
Datasheet SDS

Mouse Anti-SYT4 Recombinant Antibody (CBXS-4578) (CBMAB-S1818-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4578
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-SYT4 Recombinant Antibody (CBXS-4488) (CBMAB-S1730-CQ)

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Target: SYT4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4488
Application*: IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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