Sign in or Register   Sign in or Register
  |  

Mouse Anti-SYT4 Recombinant Antibody (CBXS-4578) (CBMAB-S1818-CQ)

This product is a mouse antibody that recognizes SYT4. The antibody CBXS-4578 can be used for immunoassay techniques such as: IF, IHC-P, WB.
See all SYT4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4578
Antibody Isotype
IgG2b
Application
IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
synaptotagmin IV
Introduction
SYT4 (Synaptotagmin 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT11.May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Entrez Gene ID
UniProt ID
Alternative Names
HsT1192
Function
Synaptotagmin family member which does not bind Ca2+ (PubMed:23999003) (By similarity).
Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (By similarity).
Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Biological Process
Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process dense core granule cytoskeletal transportISS:UniProtKB
Biological Process memoryIEA:Ensembl
Biological Process negative regulation of calcium ion-dependent exocytosisNAS:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of catecholamine secretionIGI:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of protein secretionIEA:Ensembl
Biological Process negative regulation of retrograde trans-synaptic signaling by neuropeptideIEA:Ensembl
Biological Process negative regulation of short-term neuronal synaptic plasticityIEA:Ensembl
Biological Process negative regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process neurotransmitter secretionIEA:Ensembl
Biological Process positive regulation of calcium ion-dependent exocytosisNAS:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of dendrite extensionIDA:UniProtKB1 Publication
Biological Process positive regulation of dense core granule exocytosisIEA:Ensembl
Biological Process positive regulation of glutamate secretionIEA:Ensembl
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process regulation of endocytosisIEA:Ensembl
Biological Process regulation of presynaptic dense core granule exocytosisIEA:Ensembl
Biological Process regulation of vesicle fusionIEA:Ensembl
Biological Process trans-synaptic signaling by BDNF, modulating synaptic transmissionIEA:Ensembl
Biological Process vesicle fusionIBA:GO_Central1 Publication
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane
Topology
Vesicular: 1-16
Helical: 17-37
Cytoplasmic: 38-425
PTM
Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility.
Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-SYT4 Recombinant Antibody (CBXS-4578)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare