TCN2

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. [provided by RefSeq]
Full Name
transcobalamin II; macrocytic anemia
Function
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Biological Process
Biological Process cobalamin metabolic processIEA:Ensembl
Biological Process cobalamin transportIDA:UniProtKB1 Publication
Biological Process cobalt ion transportIEA:UniProtKB-KW
Cellular Location
Secreted
Involvement in disease
Transcobalamin II deficiency (TCN2 deficiency):
Results in various forms of anemia.
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Anti-TCN2 antibodies

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Rabbit Anti-Tcn2 Recombinant Antibody (CBYJT-2325) (CBMAB-T1436-YJ)

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Target: Tcn2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-2325
Application*: E
Datasheet SDS

Rabbit Anti-Tcn2 Recombinant Antibody (CBYJT-2324) (CBMAB-T1435-YJ)

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Target: Tcn2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-2324
Application*: E
Datasheet SDS

Mouse Anti-TCN2 Recombinant Antibody (CBYJT-2323) (CBMAB-T1434-YJ)

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Target: TCN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2323
Application*: E, WB
Datasheet SDS

Mouse Anti-TCN2 Recombinant Antibody (CBYJT-2322) (CBMAB-T1433-YJ)

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Target: TCN2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-2322
Application*: WB
Datasheet SDS

Mouse Anti-TCN2 Recombinant Antibody (CBYJT-2320) (CBMAB-T1431-YJ)

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Target: TCN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-2320
Application*: E, WB
Datasheet SDS

Human TCN2 ELISA Kit (V2LY-0626-LY2919)

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Target: TCN2
Sensitivity: 0.029 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Cattle TCN2 ELISA Kit (V2LY-0626-LY2653)

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Target: TCN2
Sensitivity: 0.098 ng/mL
Detection Range: 0.2-60 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Datasheet SDS

Mouse Tcn2 ELISA Kit (V2LY-0626-LY1949)

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Target: Tcn2
Sensitivity: 0.0056 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Mouse Recombinant TCN2 protein, His Tag (V2LY-0526-LY9008)

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Target: TCN2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-430
Tag: His Tag
Datasheet SDS

Human Recombinant TCN2 protein, His Tag-2 (V2LY-0526-LY7351)

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Target: TCN2
Expressed Host: CHO Stable Cells
Sequence: Amino Acid: 1-427
Tag: His Tag
Datasheet SDS

Human Recombinant TCN2 protein, His Tag-1 (V2LY-0526-LY7350)

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Target: TCN2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-427
Tag: His Tag
Datasheet SDS

Human Recombinant TCN2 protein, His Tag (V2LY-0526-LY7349)

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Target: TCN2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-427
Tag: His Tag
In Vivo Assay
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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