TCN2

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. [provided by RefSeq]

transcobalamin II; macrocytic anemia

Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.

Biological Process cobalamin metabolic processIEA:Ensembl
Biological Process cobalamin transportIDA:UniProtKB1 Publication
Biological Process cobalt ion transportIEA:UniProtKB-KW

Secreted

Transcobalamin II deficiency (TCN2 deficiency):
Results in various forms of anemia.