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Mouse Anti-TCN2 Recombinant Antibody (CBYJT-2322) (CBMAB-T1433-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2322
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Transcobalamin II, Glu19-Trp427, Accession # P20062
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 19-427

Target

Full Name
transcobalamin II; macrocytic anemia
Introduction
TCN2 is a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. TCN2 and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene.
Entrez Gene ID
6948
UniProt ID
P20062
Alternative Names
Transcobalamin 2; Transcobalamin II; Transcobalamin II; Macrocytic Anemia; Macrocytic Anemia; TC II; TC-2; TCII; TC2
Function
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Biological Process
Biological Process cobalamin metabolic processIEA:Ensembl
Biological Process cobalamin transportIDA:UniProtKB1 Publication
Biological Process cobalt ion transportIEA:UniProtKB-KW
Cellular Location
Secreted
Involvement in disease
Transcobalamin II deficiency (TCN2 deficiency):
Results in various forms of anemia.
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For research use only. Not intended for any clinical use.

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