Mouse Anti-TCN2 Recombinant Antibody (CBYJT-2322) (CBMAB-T1433-YJ)

Name: Mouse Anti-TCN2 Recombinant Antibody (CBYJT-2322)
SKU: CBMAB-T1433-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2322

Application

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human Transcobalamin II, Glu19-Trp427, Accession # P20062

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, Trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 19-427

More Infomation

Target

Full Name

transcobalamin II; macrocytic anemia

Introduction

TCN2 is a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. TCN2 and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene.

Entrez Gene ID

6948

UniProt ID

P20062

Alternative Names

Transcobalamin 2; Transcobalamin II; Transcobalamin II; Macrocytic Anemia; Macrocytic Anemia; TC II; TC-2; TCII; TC2

Function

Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.

Biological Process

Biological Process cobalamin metabolic processIEA:Ensembl
Biological Process cobalamin transportIDA:UniProtKB1 Publication
Biological Process cobalt ion transportIEA:UniProtKB-KW

Cellular Location

Secreted

Involvement in disease

Transcobalamin II deficiency (TCN2 deficiency):
Results in various forms of anemia.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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