TEAD2

TEAD2 (TEA Domain Transcription Factor 2) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Gene Expression. Gene Ontology (GO) annotations related to TEAD2 include DNA binding transcription factor activity and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of TEAD2 is TEAD1.

Full Name

TEA domain family member 2

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Biological Process

Biological Process cellular response to retinoic acidIEA:Ensembl
Biological Process embryonic heart tube morphogenesisIEA:Ensembl
Biological Process embryonic organ developmentIBA:GO_Central1 Publication
Biological Process hippo signalingIDA:UniProtKB2 Publications
Biological Process lateral mesoderm developmentIEA:Ensembl
Biological Process negative regulation of cell deathIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Biological Process notochord developmentIEA:Ensembl
Biological Process paraxial mesoderm developmentIEA:Ensembl
Biological Process positive regulation of DNA-templated transcriptionIMP:CAFA1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process protein-containing complex assemblyIMP:CAFA1 Publication
Biological Process regulation of DNA-templated transcriptionNAS:UniProtKB1 Publication
Biological Process regulation of stem cell differentiationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process transcription by RNA polymerase IIIEA:Ensembl
Biological Process vasculogenesisIEA:Ensembl

Cellular Location

Nucleus