TGIF1

TGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, It is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.
Full Name
TGIF1
Function
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Biological Process
Biological Process negative regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Holoprosencephaly 4 (HPE4):
A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
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Anti-TGIF1 antibodies

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Mouse Anti-TGIF1 Recombinant Antibody (1D12) (CBMAB-A9058-LY)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D12
Application*: SE, E
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2839) (CBMAB-T2065-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2839
Application*: IP, WB
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2838) (CBMAB-T2064-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2838
Application*: DB, IC, IF, WB
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2837) (CBMAB-T2063-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-2837
Application*: IH
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2836) (CBMAB-T2062-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-2836
Application*: WB
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2835) (CBMAB-T2061-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2835
Application*: WB
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2834) (CBMAB-T2060-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2834
Application*: WB
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2833) (CBMAB-T2059-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2833
Application*: WB
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2832) (CBMAB-T2058-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-2832
Application*: E
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2831) (CBMAB-T2057-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2831
Application*: WB, IH
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2830) (CBMAB-T2056-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2830
Application*: WB, IH
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2829) (CBMAB-T2055-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-2829
Application*: WB, IP, IF, P, E
Datasheet SDS

Rabbit Anti-TGIF1 Recombinant Antibody (CBYJT-2828) (CBMAB-T2054-YJ)

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Target: TGIF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-2828
Application*: WB, IP
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (CBYJT-2827) (CBMAB-T2053-YJ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-2827
Application*: DB, IC
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (1B12) (CBMAB-0868CQ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B12
Application*: P, WB
Datasheet SDS

Mouse Anti-TGIF1 Recombinant Antibody (946C1a) (CBMAB-0867CQ)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 946C1a
Application*: WB, DB
Datasheet SDS

Mouse Anti-TGIF1 Monoclonal Antibody (2G6) (CBMAB-0249-LY)

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Target: TGIF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G6
Application*: IP, M, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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