THBS4

Thbs4 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. It binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Thbs4 functions in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. It may contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. It may function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner.

Full Name

Thrombospondin 4

Function

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).

Biological Process

Biological Process behavioral response to painSource:UniProtKB
Biological Process endothelial cell-cell adhesionSource:UniProtKB1 Publication
Biological Process myoblast migrationSource:UniProtKB1 Publication
Biological Process negative regulation of angiogenesisSource:UniProtKB1 Publication
Biological Process positive regulation of cell divisionSource:UniProtKB-KW
Biological Process positive regulation of endothelial cell proliferationSource:UniProtKB1 Publication
Biological Process positive regulation of neutrophil chemotaxisSource:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-tyrosine phosphorylationSource:UniProtKB1 Publication
Biological Process regulation of tissue remodelingSource:UniProtKB
Biological Process response to endoplasmic reticulum stressSource:UniProtKB
Biological Process response to unfolded proteinSource:UniProtKB-KW
Biological Process tissue remodelingSource:UniProtKB-KW

Cellular Location

Endoplasmic reticulum
Sarcoplasmic reticulum
Secreted
Secreted, extracellular space
Secreted, extracellular space, extracellular matrix