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Mouse Anti-THBS4 Recombinant Antibody (CBYJT-2949) (CBMAB-T2190-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to THBS4 (Thrombospondin 4). The antibody can be used for immunoassay techniques, such as WB.
See all THBS4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2949
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Thrombospondin-4, Ala22-Asn961 (Pro276Ala, Ala420Val), Accession # P35443
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 22-961

Target

Full Name
Thrombospondin 4
Introduction
THBS4 belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also function in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
7060
UniProt ID
P35443
Alternative Names
Thrombospondin 4; TSP4; Thrombospondin-4; TSP-4
Function
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).
Biological Process
Biological Process behavioral response to painSource:UniProtKB
Biological Process endothelial cell-cell adhesionSource:UniProtKB1 Publication
Biological Process myoblast migrationSource:UniProtKB1 Publication
Biological Process negative regulation of angiogenesisSource:UniProtKB1 Publication
Biological Process positive regulation of cell divisionSource:UniProtKB-KW
Biological Process positive regulation of endothelial cell proliferationSource:UniProtKB1 Publication
Biological Process positive regulation of neutrophil chemotaxisSource:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-tyrosine phosphorylationSource:UniProtKB1 Publication
Biological Process regulation of tissue remodelingSource:UniProtKB
Biological Process response to endoplasmic reticulum stressSource:UniProtKB
Biological Process response to unfolded proteinSource:UniProtKB-KW
Biological Process tissue remodelingSource:UniProtKB-KW
Cellular Location
Endoplasmic reticulum
Sarcoplasmic reticulum
Secreted
Secreted, extracellular space
Secreted, extracellular space, extracellular matrix
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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