TIMM44

This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. [provided by RefSeq, Jul 2016]

TIMM44 Translocase Of Inner Mitochondrial Membrane 44

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity).
Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity).

Biological Process intracellular protein transportSource:ComplexPortal1 Publication
Biological Process protein import into mitochondrial matrixSource:GO_Central1 Publication
Biological Process protein targeting to mitochondrionSource:ProtInc1 Publication

Mitochondrion inner membrane
Mitochondrion matrix