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Mouse Anti-TIMM44 Recombinant Antibody (CF438) (CBMAB-FT089LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CF438
Antibody Isotype
IgG1
Application
ELISA, WB, IHC

Basic Information

Immunogen
translocase of inner mitochondrial membrane 44 homolog (yeast)
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TIMM44 Translocase Of Inner Mitochondrial Membrane 44
Introduction
This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. [provided by RefSeq, Jul 2016]
Entrez Gene ID
Human10469
Mouse21856
UniProt ID
HumanO43615
MouseO35857
Alternative Names
MIMT44, TIM44
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity).
Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity).
Biological Process
Biological Process intracellular protein transportSource:ComplexPortal1 Publication
Biological Process protein import into mitochondrial matrixSource:GO_Central1 Publication
Biological Process protein targeting to mitochondrionSource:ProtInc1 Publication
Cellular Location
Mitochondrion inner membrane
Mitochondrion matrix
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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