TLR10

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Full Name
TLR10 Gene(Protein Coding) Toll Like Receptor 10
Function
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Biological Process
Biological Process immune responseSource:UniProtKB1 Publication
Biological Process inflammatory responseSource:GO_Central1 Publication
Biological Process innate immune responseSource:ComplexPortal1 Publication
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process positive regulation of inflammatory responseSource:InterPro
Biological Process regulation of cytokine productionSource:InterPro
Biological Process toll-like receptor 10 signaling pathwaySource:InterPro
Biological Process toll-like receptor signaling pathwaySource:GO_Central1 Publication
Cellular Location
Membrane
Topology
Extracellular: 20-576
Helical: 577-597
Cytoplasmic: 598-811
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Anti-TLR10 antibodies

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Mouse Anti-TLR10 Recombinant Antibody (CBYJT-3345) (CBMAB-T2638-YJ)

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Target: TLR10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3345
Application*: F, IH, IC, IF, P, C
Datasheet SDS

Mouse Anti-TLR10 Recombinant Antibody (CBT3240) (V2LY-0625-LY1688)

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Target: TLR10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3240
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-TLR10 Recombinant Antibody (CBT2895) (V2LY-0625-LY1659)

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Target: TLR10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2895
Application*: IC, F
Datasheet SDS

Recombinant Mouse Anti-TLR10 Antibody (CBHb319) (CBMAB-Hb1036-LY)

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Target: TLR10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb319
Application*: FC, Immuno assays
Datasheet SDS

Mouse Anti-TLR10 Recombinant Antibody (3C10C5) (CBMAB-X0409-FY)

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Target: TLR10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C10C5
Application*: F, IA
Datasheet SDS

Mouse Anti-TLR10 Recombinant Antibody (CBYY-C0064) (CBMAB-C0245-YY)

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Target: TLR10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: CBYY-C0064
Application*: F
Datasheet SDS

Mouse Anti-TLR10 Recombinant Antibody (CBYJT-3350) (CBMAB-T2644-YJ)

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Target: TLR10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-3350
Application*: E, WB
Datasheet SDS

Mouse Anti-TLR10 Recombinant Antibody (CBYJT-3349) (CBMAB-T2643-YJ)

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Target: TLR10
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3349
Application*: WB
Datasheet SDS

Mouse Anti-TLR10 Recombinant Antibody (CBYJT-3348) (CBMAB-T2642-YJ)

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Target: TLR10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3348
Application*: IH, C
Datasheet SDS

Mouse Anti-TLR10 Recombinant Antibody (CBYJT-3347) (CBMAB-T2641-YJ)

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Target: TLR10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3347
Application*: WB
Datasheet SDS

Mouse Anti-TLR10 Recombinant Antibody (CBYJT-3346) (CBMAB-T2639-YJ)

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Target: TLR10
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3346
Application*: F, MC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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