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Mouse Anti-TLR10 Recombinant Antibody (CBYJT-3350) (CBMAB-T2644-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TLR10 (Toll Like Receptor 10). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TLR10 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJT-3350
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-811 from human TLR10 (NP_112218.2) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-811

Target

Full Name
TLR10 Gene(Protein Coding) Toll Like Receptor 10
Introduction
TLR10 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil.
Entrez Gene ID
Human81793
Rat305355
UniProt ID
HumanQ9BXR5
RatC0LSK8
Alternative Names
Toll Like Receptor 10; Toll-Like Receptor 10; CD290 Antigen; CD290
Function
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Biological Process
Biological Process immune responseSource:UniProtKB1 Publication
Biological Process inflammatory responseSource:GO_Central1 Publication
Biological Process innate immune responseSource:ComplexPortal1 Publication
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process positive regulation of inflammatory responseSource:InterPro
Biological Process regulation of cytokine productionSource:InterPro
Biological Process toll-like receptor 10 signaling pathwaySource:InterPro
Biological Process toll-like receptor signaling pathwaySource:GO_Central1 Publication
Cellular Location
Membrane
Topology
Extracellular: 20-576
Helical: 577-597
Cytoplasmic: 598-811
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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