TLX2

TLX2 is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may function in tumorigenesis of gastrointestinal stromal tumors.

Full Name

T Cell Leukemia Homeobox 2

Function

Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).

Biological Process

Biological Process animal organ developmentSource:GO_Central1 Publication
Biological Process enteric nervous system developmentSource:Ensembl
Biological Process mesoderm formationSource:Ensembl
Biological Process negative regulation of dendrite morphogenesisSource:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication

Cellular Location

Nucleus