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Mouse Anti-TLX2 Recombinant Antibody (CBYJT-3440) (CBMAB-T2762-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3440
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
T Cell Leukemia Homeobox 2
Introduction
TLX2 is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may function in tumorigenesis of gastrointestinal stromal tumors.
Entrez Gene ID
3196
UniProt ID
O43763
Alternative Names
T Cell Leukemia Homeobox 2; Neural Crest Homeobox Protein; T-Cell Leukemia Homeobox 2; Homeobox Protein Hox-11L1; Homeo Box 11-Like 1; HOX11L1; NCX; T-Cell Leukemia Homeobox Protein 2; T-Cell Leukemia, Homeobox 2
Function
Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).
Biological Process
Biological Process animal organ developmentSource:GO_Central1 Publication
Biological Process enteric nervous system developmentSource:Ensembl
Biological Process mesoderm formationSource:Ensembl
Biological Process negative regulation of dendrite morphogenesisSource:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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