TM9SF4

TM9SF4 (Transmembrane 9 Superfamily Member 4) is a Protein Coding gene. Diseases related to TM9SF4 include Melanoma. An important paralog of TM9SF4 is TM9SF2.

Full Name

Transmembrane 9 Superfamily Member 4

Function

Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474).
Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576).
Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).

Biological Process

Biological Process cell adhesionSource:UniProtKB1 Publication
Biological Process phagocytosisSource:UniProtKB1 Publication
Biological Process positive regulation of protein exit from endoplasmic reticulumSource:UniProtKB1 Publication
Biological Process positive regulation of protein localization to cell surfaceSource:UniProtKB1 Publication
Biological Process protein localization to membraneSource:GO_Central1 Publication
Biological Process regulation of intracellular pHSource:UniProtKB1 Publication
Biological Process response to hypoxiaSource:UniProtKB1 Publication
Biological Process vacuolar proton-transporting V-type ATPase complex assemblySource:UniProtKB1 Publication

Cellular Location

Membrane
Golgi apparatus
Early endosome

Topology

Extracellular: 24-281
Helical: 282-302
Cytoplasmic: 303-346
Helical: 347-367
Extracellular: 368-376
Helical: 377-397
Cytoplasmic: 398-416
Helical: 417-437
Extracellular: 438-449
Helical: 450-470
Cytoplasmic: 471-501
Helical: 502-522
Extracellular: 523-535
Helical: 536-556
Cytoplasmic: 557-570
Helical: 571-591
Extracellular: 592-598
Helical: 599-619
Cytoplasmic: 620-642