TNFAIP1

TNFAIP1 was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of TNFAIP1 is developmentally regulated in a tissue-specific manner.

Full Name

TNF Alpha Induced Protein 1

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Biological Process

Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cell migrationSource:UniProtKB1 Publication
Biological Process immune responseSource:UniProtKB1 Publication
Biological Process negative regulation of Rho protein signal transductionSource:UniProtKB1 Publication
Biological Process positive regulation of DNA replicationSource:Ensembl
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processSource:UniProtKB1 Publication
Biological Process protein homooligomerizationSource:InterPro
Biological Process protein ubiquitinationSource:UniProtKB1 Publication
Biological Process stress fiber assemblySource:UniProtKB1 Publication

Cellular Location

Cytoplasm
Nucleus
Endosome
Colocalizes with RHOB in endosomes.

PTM

Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA.