Mouse Anti-TNFAIP1 Recombinant Antibody (CBYJT-3635) (CBMAB-T2991-YJ)

Name: Mouse Anti-TNFAIP1 Recombinant Antibody (CBYJT-3635)
SKU: CBMAB-T2991-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3635

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TNF Alpha Induced Protein 1

Introduction

TNFAIP1 was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of TNFAIP1 is developmentally regulated in a tissue-specific manner.

Entrez Gene ID

7126

UniProt ID

Q13829

Alternative Names

TNF Alpha Induced Protein 1; Tumor Necrosis Factor, Alpha-Induced Protein 1 (Endothelial); BTB/POZ Domain-Containing Protein TNFAIP1; HBACURD2; EDP1; BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 2; Tumor Necrosis Factor, Alpha-Induced Protein 1, Endothelial

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Biological Process

Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cell migrationSource:UniProtKB1 Publication
Biological Process immune responseSource:UniProtKB1 Publication
Biological Process negative regulation of Rho protein signal transductionSource:UniProtKB1 Publication
Biological Process positive regulation of DNA replicationSource:Ensembl
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processSource:UniProtKB1 Publication
Biological Process protein homooligomerizationSource:InterPro
Biological Process protein ubiquitinationSource:UniProtKB1 Publication
Biological Process stress fiber assemblySource:UniProtKB1 Publication

Cellular Location

Cytoplasm
Nucleus
Endosome
Colocalizes with RHOB in endosomes.

PTM

Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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