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Mouse Anti-TNFAIP1 Recombinant Antibody (CBYJT-3635) (CBMAB-T2991-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNFAIP1 (TNF Alpha Induced Protein 1). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TNFAIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3635
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNF Alpha Induced Protein 1
Introduction
TNFAIP1 was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of TNFAIP1 is developmentally regulated in a tissue-specific manner.
Entrez Gene ID
7126
UniProt ID
Q13829
Alternative Names
TNF Alpha Induced Protein 1; Tumor Necrosis Factor, Alpha-Induced Protein 1 (Endothelial); BTB/POZ Domain-Containing Protein TNFAIP1; HBACURD2; EDP1; BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 2; Tumor Necrosis Factor, Alpha-Induced Protein 1, Endothelial
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
Biological Process
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cell migrationSource:UniProtKB1 Publication
Biological Process immune responseSource:UniProtKB1 Publication
Biological Process negative regulation of Rho protein signal transductionSource:UniProtKB1 Publication
Biological Process positive regulation of DNA replicationSource:Ensembl
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processSource:UniProtKB1 Publication
Biological Process protein homooligomerizationSource:InterPro
Biological Process protein ubiquitinationSource:UniProtKB1 Publication
Biological Process stress fiber assemblySource:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Endosome
Colocalizes with RHOB in endosomes.
PTM
Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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