TNFRSF10C
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq]
Full Name
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Function
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
Biological Process
Biological Process positive regulation of apoptotic process Source:GO_Central1 Publication
Biological Process TRAIL-activated apoptotic signaling pathway Source:GO_Central1 Publication
Biological Process TRAIL-activated apoptotic signaling pathway Source:GO_Central1 Publication
Cellular Location
Cell membrane
PTM
N-glycosylated and O-glycosylated.
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Anti-TNFRSF10C antibodies
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CompareTarget: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8B8
Application*: E, E
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4G7
Application*: WB, E
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4D12
Application*: WB, E
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3A1
Application*: WB, E
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4517
Application*: WB
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DJR3
Application*: F
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3670
Application*: F, MC
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TR3.06
Application*: F, IH, WB
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3669
Application*: WB, IH, P
Target: TNFRSF10C
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3668
Application*: F, WB
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HS301
Application*: F, IC
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3667
Application*: E
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3666
Application*: F, MC
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3665
Application*: WB, P
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3664
Application*: F, IP
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3663
Application*: IH, WB
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B8
Application*: P, F
Target: TNFRSF10C
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6D347
Application*: F, WB
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TRAIL-R3-02
Application*: F
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-H47
Application*: WB
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-D44
Application*: F, I
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D346
Application*: F, IC
Target: TNFRSF10C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B1169
Application*: F, IP
Target: TNFRSF10C
Sensitivity: 0.014 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates, Ascites, tissue homogenates or other biological fluids
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: TNFRSF10C
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-235
Tag: His Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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