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Mouse Anti-TNFRSF10C Recombinant Antibody (B-H47) (CBMAB-D2309-YC)

Provided herein is a Mouse monoclonal antibody, which binds to TNF Receptor Superfamily Member 10c (TNFRSF10C). The antibody can be used for immunoassay techniques, such as WB.
See all TNFRSF10C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
B-H47
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Introduction
TNFRSF10C is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
Entrez Gene ID
UniProt ID
Alternative Names
TNF Receptor Superfamily Member 10c; Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain; TNF-Related Apoptosis-Inducing Ligand Receptor 3; Antagonist Decoy Receptor For TRAIL/Apo-2L; Decoy TRAIL Receptor Without Death Domain; Lymphocyte Inhibitor Of TRAIL; Decoy Receptor 1; TRAIL-R3; TRAILR3; DCR1;
Function
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
Biological Process
Biological Process positive regulation of apoptotic process Source:GO_Central1 Publication
Biological Process TRAIL-activated apoptotic signaling pathway Source:GO_Central1 Publication
Cellular Location
Cell membrane
PTM
N-glycosylated and O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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