TNFRSF11B
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Full Name
TNFRSF11B TNF Receptor Superfamily Member 11b
Function
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process extracellular matrix organization Source:Ensembl
Biological Process negative regulation of bone resorption Source:Ensembl
Biological Process negative regulation of odontogenesis of dentin-containing tooth Source:Ensembl
Biological Process negative regulation of osteoclast differentiation Source:Ensembl
Biological Process response to arsenic-containing substance Source:Ensembl
Biological Process response to estrogen Source:Ensembl
Biological Process response to magnesium ion Source:Ensembl
Biological Process response to nutrient Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process skeletal system development Source:ProtInc1 Publication
Biological Process extracellular matrix organization Source:Ensembl
Biological Process negative regulation of bone resorption Source:Ensembl
Biological Process negative regulation of odontogenesis of dentin-containing tooth Source:Ensembl
Biological Process negative regulation of osteoclast differentiation Source:Ensembl
Biological Process response to arsenic-containing substance Source:Ensembl
Biological Process response to estrogen Source:Ensembl
Biological Process response to magnesium ion Source:Ensembl
Biological Process response to nutrient Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process skeletal system development Source:ProtInc1 Publication
Cellular Location
Secreted
Involvement in disease
Paget disease of bone 5, juvenile-onset (PDB5):
An autosomal recessive, juvenile-onset form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB5 clinical manifestations include short stature, progressive long bone deformities, fractures, vertebral collapse, skull enlargement, and hyperostosis with progressive deafness.
An autosomal recessive, juvenile-onset form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB5 clinical manifestations include short stature, progressive long bone deformities, fractures, vertebral collapse, skull enlargement, and hyperostosis with progressive deafness.
PTM
N-glycosylated. Contains sialic acid residues.
The N-terminus is blocked.
The N-terminus is blocked.
View more
Anti-TNFRSF11B antibodies
+ Filters
Loading...
CompareTarget: TNFRSF11B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3701
Application*: IP, F
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3700
Application*: WB, N
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3699
Application*: F, IC, IF, WB
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3698
Application*: WB, IH, E
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3697
Application*: N, WB
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3696
Application*: E, IH, WB
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3695
Application*: E, F, WB
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0263
Application*: E, WB
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0491
Application*: WB, N
Target: TNFRSF11B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0273
Application*: F, IP
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXO-0479
Application*: IH, WB
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: R110
Application*: WB
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0067
Application*: E, WB
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5A11
Application*: E, IH, P, WB
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5G2
Application*: E, F, IF, WB
Target: TNFRSF11B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 340
Application*: E
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0563
Application*: N, WB
Target: TNFRSF11B
Host: Mouse
Specificity: Human
Clone: CBXO-0330
Application*: WB, IP, IF, E
Target: TNFRSF11B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: Bony1
Application*: E, F, IP
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 98A1071
Application*: WB, F, IH, IF, IP, P, C, MC
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT960
Application*: WB, IF, IC, F, E
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT961
Application*: WB, P, IF, E
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3726
Application*: IC, F
Target: TNFRSF11B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2893
Application*: IH
Target: Tnfrsf11b
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3703
Application*: WB
Target: Tnfrsf11b
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3702
Application*: WB
Target: TNFRSF11B
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXO-0518
Application*: WB
More Infomation
Hot products 
-
Rat Anti-CD300A Recombinant Antibody (172224) (CBMAB-C0423-LY)
-
Mouse Anti-CCL18 Recombinant Antibody (64507) (CBMAB-C7910-LY)
-
Mouse Anti-ACTB Recombinant Antibody (V2-179553) (CBMAB-A0870-YC)
-
Mouse Anti-AK4 Recombinant Antibody (V2-180419) (CBMAB-A1891-YC)
-
Mouse Anti-B2M Recombinant Antibody (CBYY-0050) (CBMAB-0050-YY)
-
Rabbit Anti-ALDOA Recombinant Antibody (D73H4) (CBMAB-A2314-YC)
-
Rat Anti-ADAM10 Recombinant Antibody (V2-179741) (CBMAB-A1103-YC)
-
Mouse Anti-ENO2 Recombinant Antibody (H14) (CBMAB-E1341-FY)
-
Mouse Anti-C5b-9 Recombinant Antibody (aE11) (CBMAB-AO138LY)
-
Mouse Anti-CHRNA9 Recombinant Antibody (8E4) (CBMAB-C9161-LY)
-
Rabbit Anti-B2M Recombinant Antibody (CBYY-0059) (CBMAB-0059-YY)
-
Rabbit Anti-CAMK2A Recombinant Antibody (BA0032) (CBMAB-0137CQ)
-
Mouse Anti-ALB Recombinant Antibody (V2-55272) (CBMAB-H0819-FY)
-
Mouse Anti-BAD (Phospho-Ser136) Recombinant Antibody (CBYY-0138) (CBMAB-0139-YY)
-
Mouse Anti-ACO2 Recombinant Antibody (V2-179329) (CBMAB-A0627-YC)
-
Mouse Anti-ARIH1 Recombinant Antibody (C-7) (CBMAB-A3563-YC)
-
Rabbit Anti-ABL1 (Phosphorylated Y245) Recombinant Antibody (V2-505716) (PTM-CBMAB-0465LY)
-
Rabbit Anti-CCN1 Recombinant Antibody (CBWJC-3580) (CBMAB-C4816WJ)
-
Mouse Anti-CRTAM Recombinant Antibody (CBFYC-2235) (CBMAB-C2305-FY)
-
Rat Anti-(1-5)-α-L-Arabinan Recombinant Antibody (V2-501861) (CBMAB-XB0003-YC)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
Online Inquiry