Mouse Anti-TNFRSF11B Recombinant Antibody (CBYJT-3695) (CBMAB-T3072-YJ)

Name: Mouse Anti-TNFRSF11B Recombinant Antibody (CBYJT-3695)
SKU: CBMAB-T3072-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-3695

Application

ELISA, FC, WB

Immunogen

Purified recombinant fragment of human TNFRSF11B expressed in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

Ascites

Preservative

0.03% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TNFRSF11B TNF Receptor Superfamily Member 11b

Introduction

TNFRSF11B is a member of the TNF-receptor superfamily. It is an osteoblast-secreted decoy receptor that plays a role as a negative regulator of bone resorption. TNFRSF11B specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand function in lymph-node organogenesis and vascular calcification.

Entrez Gene ID

4982

UniProt ID

O00300

Alternative Names

TNF Receptor Superfamily Member 11b; Osteoprotegerin; Tumor Necrosis Factor Receptor Superfamily, Member 11b; Osteoclastogenesis Inhibitory Factor; OCIF; OPG; Tumor Necrosis Factor Receptor Superfamily Member 11B; PDB5; TR1

Function

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Biological Process

Biological Process apoptotic process Source:UniProtKB-KW
Biological Process extracellular matrix organization Source:Ensembl
Biological Process negative regulation of bone resorption Source:Ensembl
Biological Process negative regulation of odontogenesis of dentin-containing tooth Source:Ensembl
Biological Process negative regulation of osteoclast differentiation Source:Ensembl
Biological Process response to arsenic-containing substance Source:Ensembl
Biological Process response to estrogen Source:Ensembl
Biological Process response to magnesium ion Source:Ensembl
Biological Process response to nutrient Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process skeletal system development Source:ProtInc1 Publication

Cellular Location

Secreted

Involvement in disease

Paget disease of bone 5, juvenile-onset (PDB5):
An autosomal recessive, juvenile-onset form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB5 clinical manifestations include short stature, progressive long bone deformities, fractures, vertebral collapse, skull enlargement, and hyperostosis with progressive deafness.

PTM

N-glycosylated. Contains sialic acid residues.
The N-terminus is blocked.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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