Human Recombinant TNFRSF11B protein, hFc Tag (V2LY-0526-LY5889)

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Datasheet
SDS
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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
hFc Tag
Protein Construction
This product is Human Recombinant TNFRSF11B protein, hFc Tag consist of Amino Acid: 1-401 and predicts a molecular mass of 70.3 kDa.
Molecule Mass
70.3 kDa
Sequence
Amino Acid: 1-401
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by SDS-PAGE.
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS, Glycerol, Trehalose
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
TNFRSF11B TNF Receptor Superfamily Member 11b
Function
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process extracellular matrix organization Source:Ensembl
Biological Process negative regulation of bone resorption Source:Ensembl
Biological Process negative regulation of odontogenesis of dentin-containing tooth Source:Ensembl
Biological Process negative regulation of osteoclast differentiation Source:Ensembl
Biological Process response to arsenic-containing substance Source:Ensembl
Biological Process response to estrogen Source:Ensembl
Biological Process response to magnesium ion Source:Ensembl
Biological Process response to nutrient Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process skeletal system development Source:ProtInc1 Publication
Cellular Location
Secreted
Involvement in disease
Paget disease of bone 5, juvenile-onset (PDB5):
An autosomal recessive, juvenile-onset form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB5 clinical manifestations include short stature, progressive long bone deformities, fractures, vertebral collapse, skull enlargement, and hyperostosis with progressive deafness.
PTM
N-glycosylated. Contains sialic acid residues.
The N-terminus is blocked.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant TNFRSF11B protein, His Tag (CAT#: V2LY-0526-LY5890)

Mouse Recombinant TNFRSF11B protein, hFc Tag (CAT#: V2LY-0526-LY8729)

Rhesus Recombinant TNFRSF11B protein, hFc Tag (CAT#: V2LY-0526-LY9774)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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