Tnfrsf22

Tnfrsf22 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. It protects cells against TRAIL mediated apoptosis possibly through ligand competition. It cannot induce the NF-kappa-B pathway.
Full Name
Tumor Necrosis Factor Receptor Superfamily, Member 22
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway.
Biological Process
Biological Process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source:MGI1 Publication
Biological Process positive regulation of apoptotic process Source:GO_Central1 Publication
Biological Process TRAIL-activated apoptotic signaling pathway Source:GO_Central1 Publication
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Topology
Cytoplasmic: 42-349
Helical: 350-370
Extracellular: 371-655
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Anti-Tnfrsf22 antibodies

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Rat Anti-Tnfrsf22 Recombinant Antibody (6D350) (CBMAB-D2324-YC)

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Target: Tnfrsf22
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 6D350
Application*: F
Datasheet SDS

Rat Anti-Tnfrsf22 Recombinant Antibody (Lucy1) (CBMAB-D2325-YC)

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Target: Tnfrsf22
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: Lucy1
Application*: F
Datasheet SDS

Rat Anti-Tnfrsf22 Recombinant Antibody (CBYCD-557) (CBMAB-D2323-YC)

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Target: Tnfrsf22
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYCD-557
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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