Tnfrsf22

Tnfrsf22 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. It protects cells against TRAIL mediated apoptosis possibly through ligand competition. It cannot induce the NF-kappa-B pathway.

Tumor Necrosis Factor Receptor Superfamily, Member 22

Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway.

Biological Process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source:MGI1 Publication
Biological Process positive regulation of apoptotic process Source:GO_Central1 Publication
Biological Process TRAIL-activated apoptotic signaling pathway Source:GO_Central1 Publication

Isoform 1
Cell membrane
Isoform 2
Secreted

Cytoplasmic: 42-349
Helical: 350-370
Extracellular: 371-655