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Tnfrsf22

Tnfrsf22 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. It protects cells against TRAIL mediated apoptosis possibly through ligand competition. It cannot induce the NF-kappa-B pathway.

Full Name

Tumor Necrosis Factor Receptor Superfamily, Member 22

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway.

Biological Process

Biological Process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source:MGI1 Publication
Biological Process positive regulation of apoptotic process Source:GO_Central1 Publication
Biological Process TRAIL-activated apoptotic signaling pathway Source:GO_Central1 Publication

Cellular Location

Isoform 1
Cell membrane
Isoform 2
Secreted

Topology

Cytoplasmic: 42-349
Helical: 350-370
Extracellular: 371-655

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Anti-Tnfrsf22 antibodies

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Rat Anti-Tnfrsf22 Recombinant Antibody (6D350) (CBMAB-D2324-YC)

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Target: Tnfrsf22

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 6D350

Application*: F

Rat Anti-Tnfrsf22 Recombinant Antibody (Lucy1) (CBMAB-D2325-YC)

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Target: Tnfrsf22

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: Lucy1

Application*: F

Rat Anti-Tnfrsf22 Recombinant Antibody (CBYCD-557) (CBMAB-D2323-YC)

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Target: Tnfrsf22

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBYCD-557

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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