Tnfrsf22

Tnfrsf22 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. It protects cells against TRAIL mediated apoptosis possibly through ligand competition. It cannot induce the NF-kappa-B pathway.

Full Name

Tumor Necrosis Factor Receptor Superfamily, Member 22

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway.

Biological Process

Biological Process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source:MGI1 Publication
Biological Process positive regulation of apoptotic process Source:GO_Central1 Publication
Biological Process TRAIL-activated apoptotic signaling pathway Source:GO_Central1 Publication

Cellular Location

Isoform 1
Cell membrane
Isoform 2
Secreted

Topology

Cytoplasmic: 42-349
Helical: 350-370
Extracellular: 371-655

Anti-Tnfrsf22 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Rat Anti-Tnfrsf22 Recombinant Antibody (Lucy1) (CBMAB-D2325-YC)

Datasheet

SDS

Target: Tnfrsf22

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: Lucy1

Application*: F

Rat Anti-Tnfrsf22 Recombinant Antibody (6D350) (CBMAB-D2324-YC)

Datasheet

SDS

Target: Tnfrsf22

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 6D350

Application*: F

Rat Anti-Tnfrsf22 Recombinant Antibody (CBYCD-557) (CBMAB-D2323-YC)

Datasheet

SDS

Target: Tnfrsf22

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBYCD-557

Application*: WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)