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Rat Anti-Tnfrsf22 Recombinant Antibody (Lucy1) (CBMAB-D2325-YC)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
Lucy1
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
Fusion protein, corresponding to amino acids 1-170 (the extracellular domain) of Mouse DcTRAILR2, the long splice variant of mouse DcTRAIL-R2, fused to the Fc portion of human IgG1
Specificity
Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tumor Necrosis Factor Receptor Superfamily, Member 22
Introduction
Tnfrsf22 has ubiquitous expression in limb E14.5 (RPKM 3.9), subcutaneous fat pad adult (RPKM 2.4) and 25 other tissues.
Entrez Gene ID
79202
UniProt ID
Q9ER62
Alternative Names
SOBa; Tnfrh2; Tnfrsf1al2; mDcTrailr2; 2810028K06Rik; C130035G06Rik
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway.
Biological Process
Biological Process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source:MGI1 Publication
Biological Process positive regulation of apoptotic process Source:GO_Central1 Publication
Biological Process TRAIL-activated apoptotic signaling pathway Source:GO_Central1 Publication
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Secreted
Topology
Cytoplasmic: 42-349
Helical: 350-370
Extracellular: 371-655
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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