TNK1

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Full Name
TNK1 Tyrosine Kinase Non Receptor 1
Function
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
Biological Process
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Innate immune responseManual Assertion Based On ExperimentIBA:GO_Central
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Membrane
PTM
Autophosphorylated on tyrosine residues.
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Anti-TNK1 antibodies

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Mouse Anti-TNK1 Recombinant Antibody (1B5G3;3F11H6) (CBMAB-AO1031LY)

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Target: TNK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B5G3;3F11H6
Application*: WB
Datasheet SDS

Mouse Anti-Tnk1 Recombinant Antibody (170CT7.5.4) (CBMAB-T3447-YJ)

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Target: Tnk1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 170CT7.5.4
Application*: E, WB
Datasheet SDS

Rabbit Anti-TNK1 Recombinant Antibody (CBYJT-4031) (CBMAB-T3446-YJ)

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Target: TNK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4031
Application*: WB
Datasheet SDS

Rabbit Anti-TNK1 Recombinant Antibody (CBYJT-4030) (CBMAB-T3445-YJ)

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Target: TNK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4030
Application*: WB
Datasheet SDS

Mouse Anti-TNK1 Recombinant Antibody (CBYJT-4029) (CBMAB-T3444-YJ)

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Target: TNK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4029
Application*: E, WB, P, IF, IC, F
Datasheet SDS

Mouse Anti-TNK1 Recombinant Antibody (CBYJT-4028) (CBMAB-T3443-YJ)

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Target: TNK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4028
Application*: E, WB
Datasheet SDS

Human Recombinant TNK1, Active protein, GST Tag (V2LY-0526-LY7313)

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Target: TNK1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-510
Tag: GST Tag
Datasheet SDS

Mouse Anti-TNK1 Recombinant Antibody (CBT1213) (V2LY-0625-LY2937)

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Target: TNK1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1213
Application*: WB, E
Datasheet SDS

Mouse Anti-TNK1 Recombinant Antibody (CBT2822) (V2LY-0625-LY2229)

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Target: TNK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2822
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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